Member Site Forums Rosetta 3 Rosetta 3 – Applications relax VS. backrub

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    • #1333
      Anonymous

        It seems that both relax and backrub do localiezd sampling using the Metropolis criterion. Could any one tell me the differences between them? Thank you very much!

      • #7374
        Anonymous

          Backrub is pretty complex. Have you read any of the papers on Backrub in Rosetta (look for Smith and Kortemme)?

          Relax is much simpler: it is many iterations of gradient minimization plus repacking, with varying weights on the fa_rep term to allow the structure to push over mild clashes to better minima.

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