hi
im a doctorial student in the learning process of rosetta scripts
and i was to solve a problem like i got to design a protein complex A0_B0 with known structure and known complex of A1_B1 A2_B2 all Bi are homologs
i need to design a binder A0 that binds to B0
but I just dont know how
and a teacher told me that i needed to manually docking B0 to like a1
and to use fastdesign,fastrelax, to use taskops of layerdesign,limitaromachi2,PruneBuriedUnsats,and filters like BuriedUnsatHbonds
so how am i supossed to know which mover and taskop to use if i am learning by materials and all myself
is that just experience or ?
what if i am to design a denovo binder or to do structure prediction
what combinations of movers and taskops then? ( assume i know all the meaning of single ones)