How to set up Rosetta 3 in Mac OS

This topic has 7 replies, 4 voices, and was last updated 13 years, 8 months ago by Anonymous.

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- April 6, 2011 at 3:17 am #851
  Anonymous
  Hi,
  
  I am brand new for Rosetta. I am planing to do homology modeling, protein-protein docking, and small molecule docking with Rosetta. I bought a MacBook Pro for these purposes, after consulting a few people in this field. I downloaded the most recent version of Rosetta, but I don’t know how to have Rosetta to run in my Mac. Your help will be greatly appreicated.
  
  Zhanjun
- April 6, 2011 at 9:44 am #5280
  Anonymous
  Hi,
  
  You have first to install scons on your mac. After that, just open a shell and go to rosetta_source/ folder. Then type
  
  scons bin mode=release
  or
  scons bin mode=debug
  
  to build the software. You can also use the option “-jx” where x is the number of cores you want scons to use for compiling Rosetta. Once the compilation is done, go to rosetta_source/bin/ and you’ll find the binary apps. It might be useful to look in the file rosetta_source/src/apps.src.settings to disable the apps you don’t want to be installed (because compiling everything takes much more time). To disable an app just comment the line with # character at the beginning of the line.
  
  Hope this will help.
  Alejandro
- April 6, 2011 at 3:08 pm #5285
  Anonymous
  A) All you should need on a new macbook is the “Developer Tools”, which come on a CD (DVD?) with the computer: http://developer.apple.com/technologies/tools/
  
  Scons can be installed as alejandro suggests. We also include a prepackaged Scons with Rosetta (you’ll see a link scons.py in the main code directory).
- April 6, 2011 at 7:39 pm #5291
  Anonymous
  You might also find PyRosetta easier to get started. There is a mac library version which is straightforward to install.
- April 8, 2011 at 9:10 pm #5323
  Anonymous
  Thank you very much for your help!
  
  I just installed Xcode 3.2.3 on my Mac. Then how do I use it to run the Rosetta? Sorry for these simple questions for I really want to learn!
  
  Zhanjun
- April 9, 2011 at 2:44 am #5324
  Anonymous
  Did you compile it yet?
  
  “Running rosetta” is a vague term – what do you want to do with it? Which executeable? Presumably you are trying to dome something similar to a particular publication…?
- April 11, 2011 at 3:40 pm #5341
  Anonymous
  Really appreciate your response!
  
  I want to do a few things including homology modeling, protein-protein docking, small molecule docking but I want to start with homology modeling. The platform of this forum is a great place to communicate but somehow is limited. I am wondering if you are willing to help me further over the phone so you could give me guildance step by step. If you don’t mind, could you please email me your contact phone# and the best time I can reach you? My email address is houz@karmanos.org.
  
  Thanks in advance!
- April 11, 2011 at 4:18 pm #5348
  Anonymous
  We try to keep communication on the boards as much as possible – that way it’s stored “in public”, so the next person who has a question can just see the answers, instead of re-asking it. (As a relevant aside, I’m only vaguely familiar with homology modeling anyway).
  
  The best way to make the forums work is to ask specific questions – the more specific your question is, the better I can answer. For example, you say you need help getting started, but where is started – did you get an academic license yet? Did you download the code? Did you untar it? Did you compile it? (I guess you’re at compiling but I’m not sure?)
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