I mean rather decreasing the radius of gyration.
I am folding a structure containing six helices. It folds into two three-helix-bundle units which, however, in most decoys do not interact closely with each other. In other words in most decoys the two helical units do not form common hydrophobic core.
I would like to try to force rosetta to generate higher fraction of “compact” structures.
Regarding the scores: for some random set I have averages:
After changing -rg_reweight to 2.0:
And -vdw_reweight 2.0:
so virtually there is no difference. What else I could do?
> Do you mean you want to increase the packing of the protein?Is there a sasapack score in the outputs?
> What is the average number?