Member Site › Forums › Rosetta 3 › Rosetta 3 – General › Modeling only part of the protein structure using ROSETTA › Reply To: Modeling only part of the protein structure using ROSETTA
> Hello all,
> We are trying to calculate a protein ensemble using CS-ROSETTA. We have reasonable evidences to believe that only part of the protein (C terminal part) undergoes conformational change at the condition while the rest (N terminal part) remains as a similar structure that we have already known. The protein has 146 aa, we are just wondering is there a way for ROSETTA to “Freeze” part of the protein and only do the calculation on the other part? Thanks in advance for help.