Reply To: Modeling only part of the protein structure using ROSETTA

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June 11, 2009 at 5:49 pm #4096
Anonymous

    > Hello all,
    > We are trying to calculate a protein ensemble using CS-ROSETTA. We have reasonable evidences to believe that only part of the protein (C terminal part) undergoes conformational change at the condition while the rest (N terminal part) remains as a similar structure that we have already known. The protein has 146 aa, we are just wondering is there a way for ROSETTA to “Freeze” part of the protein and only do the calculation on the other part? Thanks in advance for help.
    >
    > Qiong