Reply To: Resfile for fixed backbone design

[Anonymous]

> Hi Everyone,
>
> When using the fixed backbone design program, is it possible to specify that two residues can only be changed into the same amino acid? For instance, residue 2 can be varied into any amino acid but residue 6 must be changed into whatever residue 2 is changed into.
>
> Thank you!

Hi Smlewis,

Thanks for your response. I’ll look into the symmetry stuff. Basically, I have a beta-solenoid structure, and I would like the rungs of the solenoid to be stacked. That is, each position on each rung of the solenoid has the same amino acids.