Reply To: all-atom refinement with Relax application

[Anonymous]

thankyou for your reply. I am using a different application (not Rosetta) to generate candidate conformations for refinement. I am using Rosetta just for the all-atom refinement stage (with Relax) since my other application does not do all-atom minimization. At the moment I only have a couple dozen candidate conformations to refine, so i want to squeeze as much as I can out of the minimization step — potentially running it for a couple hours on each one.

I saw the option for fast relax and sequence relax, but my number of candidate conformations is relatively low right now, so i want to focus on how to squeeze the best minimization out of those conformations.

thanks,
Brian