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    This is a core Rosetta issue, not a PyRosetta issue. I think.

    The Dunbrack library is a huge flat file in human-readable format. For speed, the library-reading machinery attempts to serialize it and store it on disk in a binary format (Dunbrack##.lib.bin). This serialized binary format is not portable from computer to computer, but reads in to memory two orders of magnitude faster than the flat file does.

    These repeated error messages probably mean that you (or your Pyrosetta process) do not have write access to the rosetta_database directory.

    I don’t think it will harm you in the long run other than being slow. You should check that packing in general, and your Dunbrack scores in your scorefunction, are working right.