Reply To: Determine the weights of score functions

[Anonymous]

Well, like I said, the protocol is known as OptE, and it’s not published yet. The Top7 paper includes a very vague description of how score12 was originally weighted, which eventually grew into today’s OptE. There’s a paper in the works.

Short of that protocol being published, you can always try manually exploring weight-space by modifying the weights files. Try a weight set, see if it improves, try the next, etc. It’s very laborious, but it’s been done in the past…