Reply To: Modeling circular permutation and domain insertion

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April 15, 2011 at 2:04 pm #5423
Anonymous

    The length of the loops won’t matter for the relax I’ve described above. Normal loop closure does not work well on loops that long. Nothing in Rosetta (nothing I’m aware of in other programs either) works well on unstructured regions of that length; for structured regions ab initio prediction is your best bet. Do you expect your loops to be internally structured or not?