Comparative Modeling Templates for Protein with Multiple Domains

Member Site Forums Rosetta 3 Rosetta 3 – Applications Comparative Modeling Templates for Protein with Multiple Domains

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      Anonymous

        I want to build the structure of a protein that consists of multiple chains. One of my templates is homologous to the entire protein, but the other templates are only homologous to portions of the protein. I found an early post that suggests manually merging different structures into a sequence that’s homologous to the entire protein. Since this answer was posted in 2012, I wonder if is there any new approach to deal with structures that are homologous to different parts of the target?

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