How RosettaCM can perform part of C terminal domain (CTD) structure prediction without proper template structures (coordinates)

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    • September 1, 2020 at 8:21 pm #3562
      Anonymous

        Hello,

        I want to know in RosettaCM (or Robetta Server), how to generate the C terminal domain (CTD) coordinates where this query CTD domain has no corresponding template structures?

        Here is the example:

        >Query_Fasta

        VVPRRKAKIIRVRQEDEDEDE

        >Template_Fasta

        VVPRRKAKIIRVRQ

        Is it using the Fragment, or loop modeling (KIC or CCD?) or using de novo (same to ab initio?) to finish this kind of structural prediction?

        In the above example, how to predict EDEDEDE coordinates (3D structures)?

        Thanks for your help.

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