industrial example of ROSETTA modeled protein

[Anonymous]

This is a general question,

Is there any example of proteins modeled by ROSETTA  which is currently being used in industry, whether it is enzymes or therapeutics or any other biomolecules? 

Thanks.

[Anonymous]

Industry plays its cards close to the vest so we don’t know what they’ve actually used Rosetta for.  It’s also true that they’d use Rosetta as a part of a long pipeline, with many other tools used along the way.

The Kuhlman lab developed a bispecific antibody technology in collaboration with Eli Lilly.  (http://www.ncbi.nlm.nih.gov/pubmed/24463572, http://www.ncbi.nlm.nih.gov/pubmed/25774965).  I assume Lilly is finding it useful, and there is a spinoff company http://www.dualogics.com/ which is commercializing it as well.

Arzeda (http://arzeda.com/) offers enzyme design, they certainly started using Rosetta, and I assume they are using it now; probably many of their products have had Rosetta’s hand in it.

Why do you need to know?  

 

[Anonymous]

I was giving a talk with explanation of computational protein modeling in some slides and was asked the question. I included application examples from publications but didnt know of an actual example where molecules modeled with ROSETTA have been used to produce or is an ingredient of products used everyday.  I tried to search the web but as you mentioned its probably confidential info so I couldnt find anything interesting. if you know of anyother examples, whether ROSETTA or other computational modeling softwares, any comments will be appreciated. thanks for your reply.

[Anonymous]

Here’s another on the antibody thread that Andrew passed along:

http://www.sciencedirect.com/science/article/pii/S0969212616000721

 

Here’s two more from Florian:

“

There is also this paper

http://www.ncbi.nlm.nih.gov/pubmed/21168766

though I don’t know if the obtained enzyme is really used in an industrial process.

 

the enzyme here

http://www.ncbi.nlm.nih.gov/pubmed/25313043

has been patented, but I don’t know if anyone has licensed the patent and/or is marketing the enzyme

“

[Anonymous]

Also, cryptically, “and I guess kumamax is also a very good example” – I know nothing more there than google.

[Anonymous]

thanks steven.

[Author]

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