Residue is not compatible with cutpoints

[Anonymous]

Hi all,

I’m currently trying to run the CCDLoopClosureMover function in order to attach two protein domains together. 

When I try to add a single cutpoint variant around my jump point, I repeatedly get a warning that says:

“Residue 126 is not compatible with cutpoints; variant type not changed.” 

Residue 126 is the Cterminus

This warning also shows up for residue 127 (the Nterminus of the other protein domain). And thus, I cannot apply CCD to my pose because I don’t have a cutpoint variant….

I can’t seem to find anything on the internet about this issue, any help would be greatly appreciated. 

[Anonymous]

You want to remove the C-terminus variant.  

core.pose.remove_variant_type_from_residue

You’ll need to pass the variant type as an enum, the list of which is located at core.chemical.VariantType; the terminal variant will be: LOWER_TERMINUS_VARIANT, the N-teminus will have the UPPER_TERMINUS_VARIANT, that will need to be removed.  That should allow you to add the cutpoint variants, which CCD needs. 

 

 

[Anonymous]

It worked! Thank you!!

[Author]

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