I don’t have experimental data on the disordered region of a protein and tried different online prediction servers and obtained contradictory results. Disopred2 was used in the Wang et al PLoS 2011 rosetta paper but I am not sure about the accuracy. I was wondering if there were any suggestions on how to proceed?
I am Ray Wang. I would do parallel modeling runs with disordered regions predicted by different methods, and then see which ones give you make-sense convergent results.
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