Member Listing – Rich Bonneau

First Name
Middle Name
Last Name
New York University
Job Title
Research Summary
Needs update
Research Description
Ab initio protein structure prediction, modeling and design of peptide-based ligands. My lab is focused on a number of computational biology problems that, if solved, would remove key bottlenecks in biology and systems biology. We focus on two main categories of computational biology: learning networks from functional genomics data and predicting and modeling protein structure. In both areas I have played key roles in solving unsolved problems and achieving critical field-wide milestones. In the area of structure prediction we were early contributors to the Rosetta code; a platform for structure prediction, design and docking. In the area of network inference we worked on two computational methods that were used to demonstrate the first predictive genome-wide model of regulatory dynamics (i.e. the first case where a genome-wide model could predict the whole transcriptional state of cells at future time points not part of the training set). Both network inference and protein structure prediction remain grand challenges and in spite of our progress much exciting work remains to be done in the coming years as we continue to improve, scale and apply these methods.
Research Keywords
structure prediction,ab initio modeling,peptide design,peptidomimectics,macrocycles,drugs
Working with Rosetta Since