First Name
Ingemar
Middle Name
Last Name
André
Organization
Lund University
Job Title
Email
ingemar.andre@biochemistry.lu.se
Research Summary
Design of protein assembly formation and conformational change
Research Description
Modeling and design of large, symmetric protein complexes. Large protein complexes carry out some of the most complex functions in biology. Such structures are often assembled spontaneously from individual components through the process of self-assembly. A fundamental challenge in biology is to understand how protein subunits have evolved the remarkable ability to spontaneously self-assembly into complex structures and to characterize the interactions, assembly pathway and three-dimensional structures of such protein assemblies. The concept of self-assembly is relevant not only in the study of naturally occurring systems, but as a design principle in the engineering of novel protein assemblies. We develop computational methods to predict the 3D structure of protein assemblies at high resolution, and to rationally design novel protein assemblies. These are then characterized using experimental methods.
Research Keywords
symmetric protein complexes,homomultimer design,fibrils
Working with Rosetta Since
2006