First Name
Eric
Middle Name
Last Name
Fischer
Organization
Dana-Farber Cancer Institute
Job Title
Email
eric_fischer@dfci.harvard.edu
Website
Research Summary
We cultivate a multi-disciplinary and highly collaborative approach to science to tackle fundamental questions in biology and pharmacology.
Research Description
The Ubiquitin Proteasome System is involved in virtually any cellular process and frequently implicated in human diseases. The Fischer lab combines structural biology, cell biology, and high throughput biology approaches to understand the mechanistic principles that govern signaling through the ubiquitin proteasome system. We leverage these insights to propose and test new avenues of therapeutic intervention, such as targeted protein degradation or SPLiNTs. Our work has contributed to the now widespread application of targeted protein degradation in drug development and as a powerful tool to study biology.
Research Keywords
Structural biology, chemical biology, protein design
Working with Rosetta Since
2015