First Name
Anum
Middle Name
Last Name
Glasgow
Organization
Columbia University
Job Title
Email
ag4522@cumc.columbia.edu
Website
Research Summary
We aim to understand the molecular mechanisms underlying conformational changes in proteins, and we use what we learn to engineer new therapeutics.
Research Description
Our research group combines computational protein design with high-throughput biophysical techniques to study biomolecular conformational changes, towards engineering proteins and protein drugs that change conformations, interact with other molecules, and cross membranes in response to signals. Design principles for building signal-responsive, conformation-switching proteins can guide efforts to control the behavior of living systems and treat diseases without disrupting healthy cells. Our long-term goal is to engineer multi-functional proteins that respond to ligand binding and correct localization via programmed conformational changes. This work serves the public by growing our knowledge of biomolecular behavior and opening new paths to treat disease.
Research Keywords
protein design, protein allostery, protein engineering, protein therapeutics
Working with Rosetta Since
2016