First Name
Alena
Middle Name
Last Name
Khmelinskaia
Organization
Ludwig Maximilian University of Munich
Job Title
Professor
Email
akhmelin@cup.lmu.de
Research Summary
Design of protein-based biohybrid materials to (i) study complex biological processes and (ii) tackle biotechnological bottle necks.
Research Description
The group of Protein Design and Self-Assembly focuses on dissecting the physical principles of protein self-assembly. While conceptually simple, the phenomenon of self-assembly entails a fine equilibrium of a number of physical properties, which determine the dynamics and structure of the assembly architecture. We combine computational de novo protein design with protein production, in vitro model substrates and biophysical methods to systematically investigate the interplay between different types of interactions in the protein assembly process. Our goal is to create dynamic and responsive protein-based materials, by exploring protein structural flexibility and by coupling assembly to support coating or cargo encapsulation.
Research Keywords
protein design, self-assembly, biohybrid, surface coating, cargo encapsulation
Working with Rosetta Since
2019