First Name
Brian
Middle Name
Last Name
Pierce
Organization
University of Maryland
Job Title
Email
pierce@umd.edu
Research Summary
Modeling and design of immune recognition
Research Description
We develop and apply algorithms to model and design protein-protein interactions. With a major focus on immune recognition and therapeutics, we are particularly interested in T cell receptors, antibodies and vaccine design. Using computational protein design and docking algorithms, such as Rosetta, ZAFFI and ZDOCK, we are exploring ways to improve antibody and TCR targeting of viruses and tumor antigens, and to better predict uncharacterized interactions. Recent efforts in vaccine design include engineering and immunogenicity testing of a number of novel vaccine candidates to effectively target hepatitis C virus.
Research Keywords
protein-protein interactions,docking,antibody modeling,vaccine design,peptide antigens
Working with Rosetta Since
2004