First Name
William
Middle Name
Last Name
Schief
Organization
The Scripps Research Institute
Job Title
Professor
Email
schief@scripps.edu
Research Summary
HIV vaccine design; epitope-focused vaccine design; germline-targeting vaccine design.
Research Description
The Schief lab combines protein engineering tools, immunological information, vaccine delivery strategies, and bioinformatic and biophysical analyses to design and test vaccines that aim to induce tailor-made antibody responses with pre-specified epitopes, binding modes, and genetic properties. We collaborate broadly, especially for animal model tests and clinical trials of vaccine candidates. Our work is focused on HIV vaccine design but the methods and strategies are general and can be employed for other pathogens.
Research Keywords
vaccine design, protein design, epitope-focused vaccine design, germline-targeting vaccine design, antibody maturation, humoral immunity
Working with Rosetta Since
2001