First Name
Nik
Middle Name
Last Name
Sgourakis
Organization
Children's Hospital of Philadelphia
Job Title
Associate Professor with Tenure
Email
nikolaos.sgourakis@pennmedicine.upenn.edu
Research Summary
My independent research program lies at the interface of biophysics and structural biology, where experimental and computational tools are developed and applied to tackle contemporary problems in molecular immunology.
Research Description
Research at the Sgourakis Lab sheds light on the dynamic molecular processes which determine immune recognition, signaling and the formation of long-term memory against viral, tumor and autoimmune targets. To address these questions, we integrate cutting-edge structural biology tools from (NMR) Nuclear Magnetic Resonance Spectroscopy, X-ray crystallography with complementary biophysical and biochemical techniques, computational modeling and functional assays. Sgourakis lab’s efforts are done in close collaboration with the vibrant research community at Children’s Hospital of Philadelphia (CHOP) and the University of Pennsylvania.
Research Keywords
MHC-peptide-TCR interactions,peptide-protein interactions,peptide antigens,vaccine design
Working with Rosetta Since
2010