First Name
Robert
Middle Name
Last Name
Jefferson
Organization
King's College London
Job Title
Lecturer in Chemistry
Email
rob.jefferson@kcl.ac.uk
Research Summary
Modeling & design of dynamic membrane receptor complexes, Engineering membrane protein quaternary stability
Research Description
Our lab seeks to understand the underlying molecular mechanisms of membrane protein stability and function, as well as developing new receptor-based therapeutic and synthetic biology tools. Membrane proteins are constantly exposed to interactions with other proteins, whether it be oligomeric associations within the lipid bilayer, activation by peptide ligands, or coupling to downstream signaling effectors. These conformationally dynamic and transient associations are critical hubs for cellular programming, and thus are uniquely poised for engineering efforts. We apply both computational and experimental techniques to modelling and design of dynamic membrane protein complexes for cellular engineering.
Research Keywords
membrane complexes, quaternary stability
Working with Rosetta Since
2024