First Name
Longxing
Middle Name
Last Name
Cao
Organization
Westlake University
Job Title
Assistant Professor
Email
caolongxing@westlake.edu.cn
Research Summary
developing new de novo protein design methods and apply these methods for cutting-edge therapeutics
Research Description
My research interests focus on developing new de novo protein design methods and apply these methods for cutting-edge therapeutics. I am particularly interested in the following directions: 1. Designing de novo protein therapeutics by targeting tumor specific cells surface marks and immune modulators. 2. Designing conformational switches that can sense environment stimulus (ion, light, small molecules, et al.), and explore its applications in synthetic biology and immunotherapy. 3. Developing function-oriented approach for de novo protein scaffold generation and sequence design. 4. Developing new protein structure generation and sequence design methods utilizing the advanced deep learning techniques.
Research Keywords
Protein design, Protein interface design, Protein switch design
Working with Rosetta Since
2017