You’ll want to give each instance of rosetta a different random seed.
To do this, you’ll use two flags in your command line: -constant_seed and -jran
The integer that follows the -jran flag should be between 1 million and 4 million.
> I would like to run multiple instances of rosetta on a cluster in order to speed
> up decoy generation.
> How can I ensure that each of the decoys is original so that the conformational
> space is searched without duplicating decoys?
> Does rosetta have a way of creating a random seed and if so how does this alter
> the decoy generation?
> Mathew Smith