Member Site Forums Rosetta 3 Rosetta 3 – General Homology modeling Reply To: Homology modeling

#4153
Anonymous

    Do you have disulfides in your protein?

    As of 3.0, the “detect_disulfides” flag defaults to true, you can try turning this to false, especially if you do not have disulfides.

    There is a flag “fix_disulf” which lets you specify where you know the disulfides are – I’ve never used it and have no idea if it’s compatible with loop modeling.