A protein is composed of N and C domains.
In the experiment, the protein was cut into these two domains and each of them was solved by crystallography.
However, the structure of the loop linking these two domains was unknown.
Therefore, I hope to predict the loop structure so that it can link the solved two domains.
How to achieve this goal?
Look forward to the reply.
There’s some additional protocols in the works for this sort of problem, but I don’t believe they’ve been published yet. (Keep an eye out for “Loop Hashing” from the Baker Lab, though it may be a while before that’s published.)